melanoma cell growth — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T10104	3,4-Dihydroxybenzylamine hydrobromide	NSC 263475 hydrobromide	Others , DNA/RNA Synthesis
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activit...		Others , DNA/RNA Synthesis
T28206	NSC49652	NSC 49652,NSC-49652	Apoptosis
	NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.		Apoptosis
T28145	ND-322 HCl	ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl	MMP
	ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.		MMP
T17195	UC-112		Others
	UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).		Others
T11209	EOAI3402143		DUB
	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.		DUB
T17228	Sabizabulin	ABI-231,VERU-111	Microtubule Associated
	Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervica...		Microtubule Associated
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
T36674	DMU-212		Apoptosis , ERK
	DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2...		Apoptosis , ERK
T29973	AMG-628	AMG628,AMG 628,CHEMBL226574,UNII-28J966TN3X
	AMG-628 is an effective and ATP-competitive RAF kinase inhibitor. AMG-628 has been shown to inhibit growth and induce cell cycle arrest and apoptosis in colon and melanoma cell lines with B-RAFV600E mutations.
T12003	Mensacarcin		Others
	Mensacarcin, a highly complex polyketide compound, exhibits multifaceted effects on cellular processes. Specifically, it targets mitochondria, perturbs energy metabolism within these organelles, and activates caspase-dep...		Others
T36497	CAY10735	CAY10735
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mese...
T68523	AMG-628, (S)-
	AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1...
T60821	ACA-28
	ACA-28 (compound 2a) is a potent modulator of ERK MAPK signaling that induces apoptosis with ERK hyperactivation therefore selectively inhibits cancer cell growth. The IC 50 values of ACA-28 against melanoma cells (SK-ME...
T72188	Nicotinamide Hydrochloride	Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride is a form of vitamin B3 or niacin that inhibits sirtuin 2 ( SIRT2 ) activity in vitro , with an EC 50 of 2 μM. Nicotinamide Hydrochloride inhibits up to 90% melanoma cell number and increases c...
T71736	AMG-628, (R)-
	AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 ...
T36460	CAY10736	CAY10736
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal ...
T83756	S1H TFA	Site 1-binding Helix
	S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered b...
T79143	MS934		MEK
	MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM. It holds potential for researching various human cancers including melanoma, ...		MEK
T82605	DB21, Galectin-1 Antagonist		Galectin
	DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans on cell surfaces. This compound enhances the inhibition of ...		Galectin